Synergistic interaction of sprouting and intussusceptive angiogenesis during zebrafish caudal vein plexus development

Intussusceptive angiogenesis (IA) is a complementary method to sprouting angiogenesis (SA). The hallmark of IA is the formation of trans-capillary tissue pillars, their fusion and remodelling of the vascular plexus. In this study, we investigate the formation of the zebrafish caudal vein plexus (CVP) in Tg(fli1a:eGFP) y7 and the synergistic interaction of IA and SA in crafting the archetypical angioarchitecture of the CVP.